tuberculosis under ordinary circumstances, but L. succeeded in producing a swelling of the lymphic glands nearest the seat of inoculation in mice to which he administered phlorizin. The mice for the most part died from the effects of phlorizin before fourteen days, but those which outlived this period were affected with tuberculosis of the lymph glands. Guinea-pigs, which are quite susceptible to tuberculosis, did not seem to be made more so by the administation of phlorizin. Experiments with the bacillus of glanders gave very striking results. White mice are insusceptible to glanders under ordinary circumstances. In all, forty-nine white mice were fed with cakes saturated with 1-20 solution of phlorizin in alcohol. The cakes were first allowed to dry in order to drive off the alcohol. The mice were inoculated with pure cultures of glanders bacilli, and then fed on these dried cakes. Of the forty-nine mice treated in this way, forty-seven died of glanders. Forty-eight mice inoculated with glanders cultures without the administration of phlorizin all remained perfectly healthy. The control mice fed with phlorizin without inoculation died, but they remained alive much longer than those which were inoculated. The former lived two or three weeks, whereas the latter died in three to nine days. It is evident that white mice lose their immunity from glanders when they are dosed with phlorizin. L. holds that whether this result is brought about by the production of sugar or not, it must be caused by some chemical change in the tissues. PHYSIOLOGY AND EXPERIMENTAL THERAPEUTICS. BY GEORGE T. KEMP, PH. D., Associate Director of the Department of Physiology and Experimental Therapeutics, REGULATION OF OXIDIATION IN THE TISSUES BY THE NERVOUS SYSTEM CON SIDERED IN RELATION TO THE SIZE OF THE ANIMAL. 1 Richet finds that dogs of different sizes conform to the law of Regnault and Reiset for different animals of different sizes. [Regnault and Reisset's law is that the chemical activity in gaseous metabolism per pound of weight of living tissue, is inversely as the size of the animal. For example, two dogs of 50 lbs. each will present more skin and lung surface than one dog of 100 lbs., hence each pound 1 Regulation par le système nerveux, des combustions respiratoires, en rapport avec la taille de l'animal, by Charles Richet, Comptes Rendus, Acad. des Sciences, July 29. 1889 p. 191. PHYSIOLOGY AND EXPERIMENTAL THERAPEUTICS. 349 must make more heat to keep the temperature of the dog up to normal.-REV.] Richet finds that the amount of oxygen consumed and of carbon dioxide given off is strikingly similar in different dogs, when considered in ratio to their surface exposed to the air. Under the influence of large doses of chloral, this relationship is lost, and we have, roughly speaking, about the same amount of chemical activity per kilogramme of dog, in all dogs, whether they be large or small. The author emphasizes the control, by the nervous system, of the chemical activity and the production of heat in the tissues, and points out that when the central nervous system is under the influence of chloral, it can no longer cause increased heat production as required in the tissues, and the temperature falls about thirty per cent. in large dogs, and as much as seventy per cent. in small dogs, owing to the relatively larger surface in the latter from which heat is lost. COMPENSATING HYPERTROPHY OF THE SUPRA RENAL BODIES.2 Dr. Stilling worked on young rabbits, and found that upon extirpating one supra-renal body the other hypertrophied as much as seventyfive per cent. If a portion of a supra-renal body is left in situ, it will grow to its natural size and be of normal structure. After extirpation of a supra-renal capsule, then often develops secondary glands like the supra-renal bodies in structure. These may develop anywhere along the cava in the neighborhood of the kidneys. From these facts the author draws the conclusion that the supra-renal bodies have a function to perform in post embryonal life, and are not simply remnants of ancestral history, or at most, of use to the embryo. EFFECT OF LIGATING THE HEPATIC ARTERY.* The ligation of the hepatic artery has been made by former investigators to study its effect on the secretion, but the authors claim that they are the first to make a study of the effect of such ligature upon its glycogenic function. Kottmeier and Küthe have observed a suppression of the secretion of bile, and Cohnheim and Litten have found a veritable necrosis to follow a ligature of the hepatic artery. Arthaud and Butte have made five experiments on dogs, and each time have obtained an identical result. The operations are all made with antiseptic precautions, and the animals recover rapidly from the effects Ueber die Compensatorische Hypertrophie der Nebennieren, by Dr. H. Stilling, "Virchow's Archiv., 1889, vol. 118, pp. 569-5575. 3 Compare experiments 6 and 15. Note sur les effects de la ligature de l'artèrie hépatique, by Messrs. Arthaud and Butte, Comptes Rend, de la Société de Biologie, Dec. 6, 1889, pp. 674-676. of the operation. They remain pretty active for three or four days, and eat a little porridge (soupe au lait). At the end of the fourth day, they become restless, grow weak, and rapidly give out, dying on the fifth or sixth day. Examination of the liver made immediately and some hours after death, show a "total absence of glycogen and glucose. cause of death is apparently the cessation of the glycogenic function of the liver. The [The results of these observations with those of Cohnheim and Litten, all agree in supporting the view which is daily increasing among physiologists, that the portal blood brings material for the liver to work on, while the blood from the hepatic artery is more important, though much the smaller supply, in that it maintains the life of the liver cells. Tying the portal vein does not cause death in any such fashion as Arthnaud and Butte have found for the hepatic artery.-REV.] MISCELLANEOUS. AWARDS OF THE BROOKLYN HEALTH EXHIBITION. The Local Committee of Arrangements of the American Public Health Association has made the following awards to the exhibitors at the Health Exhibition which was held in Brook'yn in October and November, 1889. TESTIMONIALS. American Washable Wall Paper Company, Deckertown, N. J. For Wall Papers that Wash and contain no arsenic. Edward Atkinson, LL. D., Boston, Mass. For Aladdin Cooker and Aladdin Oven. Backus Portable Steam Heater Company, New York. For the Backus Patent Portable, Open, Reflecting and Steam Radiating Heater. Connolly Manufacturing Company, Brooklyn, N. Y. For Connolly Patent Globe Trap and Hopper Clamps. John Cooper, Brooklyn, N. Y. centering Sewer and Drain Pipe. For Vitrified Salt-glazed, Self Dermigny & Company, New York. For the Family Ice Machine. Durham House Drainage Company, New York. For the Durham System of House Drainage. Joseph Guy, New York. For Guy's Coronet Water-Closet System for out-door use. Tub. Henry Huber & Company, New York. For Indurated Fibre Bath The Dr. Jaeger Sanitary Woolen System Company, New York. For Pure Woolen Clothing. Lewis G. Janes, M. D., New York. For Health Lift. Mark's Adjustable Folding Chair Company, New York. For Ad. justable Parlor, Library, Reclining and Invalid Chairs. McKesson & Robbins, New York. For Chemicals, Laboratory Apparatus for Health Officers, and Sanitary Goods. E. Merck, New York. For Rare and Valuable Medical Chemicals Illustrating Modern Progress in Medical Chemistry. Miss C. N. Neal, New York. For the Neal Improved Infants' Portable Bath-Tub. J. J. Powers, Sanitary Engineer, Brooklyn, N. Y. For Plan of Sewage Disposal Works. Rochester Sewer Pipe Company. Otis & Gorsline, Rochester, N. Y. For Highly Vitrified Salt-Glazed Sewer and Drain Pipe. Seabury & Johnson, New York. For Antiseptics and Sanitary Spit cups. A. G. Spalding & Brothers, New York. For Gymnastic Apparatus and Anthropometric Instruments. Rushville School Furniture Company, Rushville, Ind. For School Furniture. C. B. Tefft, M. D., Utica, N. Y. For Family Garbage Burner. Warner Brothers, New York. For Dr. Warner's Health Under-wear, Manufactured from Camel's Hair and Natural Wool. George H. Warner, New York. For the Engle Fire Closet, for the cremation of garbage and other obnoxious substances. Wells Rustless Iron Company, New York. For Rustless WroughtIron Steam, Gas, and Water Pipe. W. Scott West, New York. For Plan of Filtration and Water Purification-the West Elevated Filter Beds. Wilmot Castle & Co., Rochester, N. Y. Cooker and Steam Sterilizer. HONORABLE MENTION. For the Arnold Steam Armour & Co., Chicago, Ill. For Armour's Extract of Beef. Boynton Furnace Company, New York. For Gas-tight Self-Cleaning Furnace. Theodore Bury, Cleveland, O. For Window Ventilator. Bush Manufacturing Company, New York. For Bovinine. Cibil Company, Boston, Mass. For Cibil's Fluid Beef Extract. DuBois Manufacturing Company, New York. For McClellan AntiSiphon Trap Vent. Echo Farm Company, Litchfield, Conn. Echo Farm Products, Milk and Butter. Franco-American Food Company, New York. For French Soups and Biardot's Soups for Invalids. Daniel Green & Company, New York. For the Alfred Dolge Felt Shoes and Slippers. Mrs. L. Higham, Brooklyn, N. Y. For Health Waists. Henry Huber & Company, New York. For Boyle's Patent Pneumatic Water-Closet. P. H. Kahler & Sons, New York. For Boots and Shoes made on Hygienic Principles. Thomas Leeming & Company, New York. For Nestle's Swiss Milk and Milk Food for Infants and Invalids. Malted Milk Company, Racine, Wis. For Malted Milk for Infants. Maltine Manufacturing Company, New York. For Maltine. J. A. Missud, New Orleans, La. For the Missud Sewer Pipe. Murdock Liquid Food Company, Boston, Mass. For Murdock Liquid Food. Myer's Sanitary Depot, New York. For Siphon Water-Closet "A. G. M." Patent Cereal Food Company, New York. For "Rex Wheat" Cereal Food. Red Cross Section, Brooklyn, N. Y. For Completeness of Paraphernalia. Reed & Carnrick, New York. For Peptonized Cod-Liver Oil and Milk and Beef Peptonoids, and Infants' Foods. Richardson & Morgan Company, New York. For Improved Combination Heaters-Steam and Hot Water. W. D. Van Duzer, Minneapolis, Minn. For Minnesota Sewer Flusher. OPERATIONS ON THE PROSTATE. Dr. Wm. T. Belfield, 612 Opera House Building, Chicago, Ill., U. S. A., respectfully solicits information concerning unpublished cases of operations upon the prostate, especially for the relief of the so-called hypertrophy of the organ. |