Genomics, Proteomics, and Clinical Bacteriology: Methods and ReviewsNeil Woodford, Alan P. Johnson Springer Science & Business Media, 2008. febr. 5. - 398 oldal Gazing into crystal balls is beyond the expertise of most scientists. Yet, as we look further into the 21st century, one does not have to be Nostradamus to predict that the current genomics and proteomics "revolution" will have an immense impact on medical bacteriology. This impact is already being re- ized in many academic departments, and although encroachment on routine diagnostic bacteriology, particularly in the hospital setting, is likely to occur at a slower pace, it remains nonetheless inevitable. Therefore, it is important that no one working in bacteriology should find themselves distanced from these fundamental developments. The involvement of all clinical bacteriologists is essential if the significant achievements of genome sequencing and analysis are to be turned into tangible advances, with resulting benefits for patient care and m- agement. It is our hope that Genomics, Proteomics, and Clinical Bacteriology: Methods and Reviews will play a part in bringing such a development to fruition. The advances in genomics and proteomics have already given us frequent opportunities to reassess our knowledge and understanding of established b- terial adversaries, and have provided us with the means to identify new foes. The new knowledge gained is enabling us to reconsider, for example, our c- cepts of bacterial pathogenicity, phylogeny and novel targets for antibacterial chemotherapy. These topics, and others, are considered in Genomics, Proteomics, and Clinical Bacteriology: Methods and Reviews. |
Tartalomjegyzék
3 | |
Retrieving and Manipulating Sequences | 17 |
An Overview | 29 |
Digging for Data | 47 |
Insertion Sequence Elements Transposons | 71 |
Exploring and Exploiting Bacterial Proteomes | 115 |
PART IIAPPLICATION OF GENOMICS TO DIAGNOSTIC BACTERIOLOGY | 139 |
Future ProbeBased Strategies | 167 |
Realistic Goal or Holy Grail? | 213 |
Más kiadások - Összes megtekintése
Genomics, Proteomics, and Clinical Bacteriology: Methods and Reviews Neil Woodford,Alan P. Johnson Nincs elérhető előnézet - 2004 |
Genomics, Proteomics, and Clinical Bacteriology: Methods and Reviews Neil Woodford,Alan P. Johnson Nincs elérhető előnézet - 2010 |
Genomics, Proteomics, and Clinical Bacteriology: Methods and Reviews Neil Woodford,Alan P. Johnson Nincs elérhető előnézet - 2004 |
Gyakori szavak és kifejezések
16S rRNA gene Acad aeruginosa alignment amplicons amplification analysis ancestral genotype antibacterial antibiotic antibiotic resistance approach array assay bacterial pathogens bacterial species Bacteriol biology Campylobacter Campylobacter jejuni cell characterization chromosome Clin Clinical Bacteriology clonal complex clones codon comparative genomics Complete genome sequence database detection diagnostic disease diversity DNA sequences electrophoresis encoding enterica enzyme Escherichia coli evolutionary fluor fluorescence fragments function GenBank genetic genome sequence genomic islands genotypes Helicobacter pylori homologous host hybridization identification infection insertion integron isolates jejuni laboratory loci methods microarray microbial Microbiol Microbiology MLST molecular molecule mutants Mycobacterium NAATs NCBI novel nucleic acid nucleotide oligonucleotide organisms phage phenotypic phylogenetic plasmid pneumoniae polymerase population potential primers probe Proc proteins Proteomics rDNA real-time PCR recombination resistance Salmonella samples signal Staphylococcus aureus strains Streptococcus structure tags target sequence technologies tion transposable elements transposase transposition transposon trees tuberculosis vitro vivo