Cell and Tissue Reaction EngineeringSpringer Science & Business Media, 2008. szept. 30. - 363 oldal The completion of the Human Genome Project and the rapid progress in cell bi- ogy and biochemical engineering, are major forces driving the steady increase of approved biotech products, especially biopharmaceuticals, in the market. Today mammalian cell products (“products from cells”), primarily monoclonals, cytokines, recombinant glycoproteins, and, increasingly, vaccines, dominate the biopharmaceutical industry. Moreover, a small number of products consisting of in vitro cultivated cells (“cells as product”) for regenerative medicine have also been introduced in the market. Their efficient production requires comprehensive knowledge of biological as well as biochemical mammalian cell culture fundamentals (e.g., cell characteristics and metabolism, cell line establishment, culture medium optimization) and related engineering principles (e.g., bioreactor design, process scale-up and optimization). In addition, new developments focusing on cell line development, animal-free c- ture media, disposables and the implications of changing processes (multi-purpo- facilities) have to be taken into account. While a number of excellent books treating the basic methods and applications of mammalian cell culture technology have been published, only little attention has been afforded to their engineering aspects. The aim of this book is to make a contribution to closing this gap; it particularly focuses on the interactions between biological and biochemical and engineering principles in processes derived from cell cultures. It is not intended to give a c- prehensive overview of the literature. This has been done extensively elsewhere. |
Tartalomjegyzék
11 | |
4 | 21 |
15 | 44 |
20 | 50 |
24 | 57 |
4 | 62 |
26 | 66 |
29 | 76 |
Insect CellBased Recombinant Protein Production | 263 |
Bioreactors for Bioartificial Organs | 279 |
69 | 293 |
List of Symbols | 310 |
72 | 338 |
Agent Candidates Conclusions 8 6 Questions and Problems | 342 |
348 | |
75 | 355 |
Más kiadások - Összes megtekintése
Cell and Tissue Reaction Engineering Regine Eibl,Dieter Eibl,Ralf Pörtner,Gerardo Catapano,Peter Czermak Nincs elérhető előnézet - 2009 |
Cell and Tissue Reaction Engineering Regine Eibl,Dieter Eibl,Ralf Pörtner,Gerardo Catapano,Peter Czermak Nincs elérhető előnézet - 2008 |
Cell and Tissue Reaction Engineering Regine Eibl,Dieter Eibl,Ralf Pörtner,Gerardo Catapano,Peter Czermak Nincs elérhető előnézet - 2009 |
Gyakori szavak és kifejezések
aeration baculovirus batch bioartificial organs biomass Bioprocess bioreactor design bioreactor types Biotechnol Bioeng BioWave bubble columns callus carriers cell compartment cell concentration cell culture cell culture bioreactors cell damage cell growth cell line cell retention cell specific cell suspension cell-based chemostat coefficient cultivation culture medium Cytotechnol dialysis diameter disposable bioreactors dissolved oxygen Eibl Fassnacht fed-batch fixed bed bioreactor flow rate fluid glucose glutamine hairy roots high cell densities hollow fiber hybridoma hybridoma cells immobilization impeller increase insect cells kinetic liquid liver Lüllau mass transfer MCCRs membrane bioreactors metabolic metabolites microcarriers mmol monoclonal antibodies nutrients optimization oxygen concentration oxygen transfer Ozturk parameters perfusion plant cell plant cell cultures plasma Pörtner power input recombinant protein scale scale-up secondary metabolite Sect serum shear stress solute sparged sparger specific growth rate stirred bioreactors stirrer substrate surface suspension cells suspension cultures tion tissue engineering transport uptake rate vessel virus volume